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1. Ageing & Sports

Author

Müller P, Stiebler M, Schwarck S, Haghikia A, and Düzel E

Subjects
Sports medicine, RC1200-1245
Abstract

Physical activity is a low-cost intervention in primary and secondary prevention of numerous chronic diseases (e.g., cardiovascular diseases, metabolic diseases, sarcopenia, cancer, dementia). Furthermore, several epidemiological, observational and randomized controlled studies have shown positive effects of physical activity on cognition and reduced risk of neurodegenerative diseases.Industrial societies are currently experiencing a tremendous demographic change with an unprecedented increase in absolute and relative numbers of elderly adults. This demographic change entails a plethora of challenges for the healthcare system. As the prevalence of many (neurodegenerative) diseases correlates with age, the number of persons affected by age-related diseases will rise.In this context, non-pharmacological concepts of healthy aging are becoming more attention. Especially lifestyle interventions (e. g. physical activity) are becoming increasingly important and could play a key role in healthy aging and prevention of neurodegenerative diseases. Recent research has shown that physical activity and/or physical exercise benefits cognition and brain plasticity across the lifespan.In this review we summarize (i) the effects of physical activity and/or physical exercise on brain plasticity, (ii) the role of physical activity and/or physical exercise in the prevention and therapy of dementia, and (iii) potential neurobiological mechanisms of physical activity-induced brain plasticity.Key Words: Age-related Diseases, Brain Plasticity, Physical Exercise, Prevention

Published
2021
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4. Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Author

Ferrell, Marc, primary, Wang, Zeneng, additional, Anderson, James T., additional, Li, Xinmin S., additional, Witkowski, Marco, additional, DiDonato, Joseph A., additional, Hilser, James R., additional, Hartiala, Jaana A., additional, Haghikia, Arash, additional, Cajka, Tomas, additional, Fiehn, Oliver, additional, Sangwan, Naseer, additional, Demuth, Ilja, additional, König, Maximilian, additional, Steinhagen-Thiessen, Elisabeth, additional, Landmesser, Ulf, additional, Tang, W. H. Wilson, additional, Allayee, Hooman, additional, and Hazen, Stanley L., additional

Published
2024
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5. A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

Author

Ferrell, Marc, Wang, Zeneng, Anderson, James T., Li, Xinmin S., Witkowski, Marco, DiDonato, Joseph A., Hilser, James R., Hartiala, Jaana A., Haghikia, Arash, Cajka, Tomas, Fiehn, Oliver, Sangwan, Naseer, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Landmesser, Ulf, Tang, W. H. Wilson, Allayee, Hooman, and Hazen, Stanley L.

Published
2024
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10. Prognostic Value of Gut Microbe‐Generated Metabolite Phenylacetylglutamine in Patients with Heart Failure

Author

Tang, W. H. Wilson, primary, Nemet, Ina, additional, Li, Xinmin S., additional, Wu, Yuping, additional, Haghikia, Arash, additional, Witkowski, Marco, additional, Koeth, Robert A., additional, Demuth, Ilja, additional, König, Maximilian, additional, Steinhagen‐Thiessen, Elisabeth, additional, Bäckhed, Fredrik, additional, Fischbach, Michael A., additional, Deb, Arjun, additional, Landmesser, Ulf, additional, and Hazen, Stanley L., additional

Published
2023
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11. Cholesterol crystals at the culprit lesion in patients with acute coronary syndrome are associated with worse cardiovascular outcomes at two years follow up - results from the translational OPTICO-ACS study program (R2)

Author

Nelles, Gregor, primary, Abdelwahed, Youssef S., additional, Seppelt, Claudio, additional, Meteva, Denitsa, additional, Stähli, Barbara E., additional, Rai, Hirmanshu, additional, Seegers, Lena M., additional, Sieronski, Lara, additional, Musfeldt, Johanna, additional, Gerhardt, Teresa, additional, Riedel, Matthias, additional, Skurk, Carsten, additional, Haghikia, Arash, additional, Sinning, David, additional, Dreger, Henryk, additional, Knebel, Fabian, additional, Trippel, Tobias D., additional, Krisper, Maximillian, additional, Klotsche, Jens, additional, Joner, Michael, additional, Landmesser, Ulf, additional, and Leistner, David M., additional

Published
2023
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12. Anti-CD19 CAR T cells for refractory myasthenia gravis

Author

Haghikia, Aiden, primary, Hegelmaier, Tobias, additional, Wolleschak, Denise, additional, Böttcher, Martin, additional, Desel, Christiane, additional, Borie, Dominic, additional, Motte, Jeremias, additional, Schett, Georg, additional, Schroers, Roland, additional, Gold, Ralf, additional, and Mougiakakos, Dimitrios, additional

Published
2023
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13. The artificial sweetener erythritol and cardiovascular event risk.

Author

Witkowski, Marco, Nemet, Ina, Alamri, Hassan, Wilcox, Jennifer, Gupta, Nilaksh, Nimer, Nisreen, Haghikia, Arash, Li, Xinmin, Wu, Yuping, Saha, Prasenjit, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, Cajka, Tomas, Landmesser, Ulf, Tang, W, Hazen, Stanley, and Fiehn, Oliver

Subjects
Humans, Sweetening Agents, Prospective Studies, Erythritol, Myocardial Infarction, Heart
Abstract

Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200 ), circulating levels of multiple polyol sweeteners, especially erythritol, were associated with incident (3 year) risk for major adverse cardiovascular events (MACE; includes death or nonfatal myocardial infarction or stroke). Subsequent targeted metabolomics analyses in independent US (n = 2,149, NCT00590200 ) and European (n = 833, DRKS00020915 ) validation cohorts of stable patients undergoing elective cardiac evaluation confirmed this association (fourth versus first quartile adjusted hazard ratio (95% confidence interval), 1.80 (1.18-2.77) and 2.21 (1.20-4.07), respectively). At physiological levels, erythritol enhanced platelet reactivity in vitro and thrombosis formation in vivo. Finally, in a prospective pilot intervention study ( NCT04731363 ), erythritol ingestion in healthy volunteers (n = 8) induced marked and sustained (>2 d) increases in plasma erythritol levels well above thresholds associated with heightened platelet reactivity and thrombosis potential in in vitro and in vivo studies. Our findings reveal that erythritol is both associated with incident MACE risk and fosters enhanced thrombosis. Studies assessing the long-term safety of erythritol are warranted.

Published
2023

14. Predictors for Adherence to Recommended Anticoagulation after Stroke Unit Discharge in Patients with Atrial Fibrillation

Author

Theresa Frank, Jens Neumann, Anne Assmann, Stefanie Schreiber, Aiden Haghikia, Maria Barleben, Michael Sailer, and Michael Goertler

Subjects
atrial fibrillation, anticoagulation, adherence, direct oral anticoagulant, stroke prevention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Introduction: Non-adherence to recommended secondary preventive anticoagulation in stroke patients with atrial fibrillation (AF) is a common phenomenon, although the introduction of direct oral anticoagulants (DOACs) has simplified anticoagulation management for physicians as well as for patients. Methods: We examined the adherence of secondary preventive anticoagulation in AF patients after re-integration in their social environment 6–12 weeks after stroke unit and rehabilitation clinic treatment and analyzed for predictors for adherence and non-adherence. We conducted a telephone survey in consecutive patients treated between January 2013 and December 2021 at our institutional stroke unit with an acute cerebrovascular ischemic event, and we analyzed discharge letters of rehabilitation clinics of those patients not anticoagulated at follow-up. All patients had known or newly diagnosed AF, and in all, we had recommended secondary preventive anticoagulation. Results: Follow-up information about anticoagulant intake could be obtained in 1,348 of 1,685 patients (80.0%) treated within the study period. Anticoagulation rate was 91.5%, with 83.6% of patients receiving DOACs and 7.9% receiving vitamin K antagonists (VKAs). Adherence to recommended anticoagulation was associated with intake of the recommended anticoagulant already at discharge (adjusted odds ratio [OR], 18.357; confidence interval [CI], 9.637–34.969), recommendation of a specific DOAC and dose (in contrast to “DOAC” as drug category) (adjusted OR, 2.971; CI, 1.173–7.255), a lower modified Rankin Scale at discharge (per point; adjusted OR, 0.813; CI, 0.663–0.996), younger age (per year; OR, 0.951; CI, 0.926–0.976), and the absence of peripheral vascular disease (adjusted OR, 0.359; CI, 0.173–0.746). In patients already anticoagulated at discharge, adherence was 98.5%, irrespective of a patient’s age, functional deficit at discharge, and peripheral vascular disease. Avoidable obstacles for non-adherence in patients not on anticoagulants at stroke unit discharge were (1) non-implementation of recommended anticoagulation by rehabilitation physicians predominantly in patients with moderate-severe or severe stroke disability (2.1%), (2) delegation of anticoagulation start from rehabilitation physicians to general practitioners/resident radiologists (1.3%), and (3) rejection of recommended anticoagulation because of patients’ severe stroke disability (0.5%). Non-avoidable obstacles were contraindications to anticoagulation (2.1%) and patients’ refusal (0.7%). Conclusions: Commencing drug administration already during stroke unit hospitalization and providing an explanation for the selection of the recommended anticoagulant in discharge letters ensures high adherence at patients’ re-integration in their social environment after acute stroke treatment. If drug administration cannot be commenced before discharge, education of rehabilitation physicians by stroke physicians and the involvement of stroke physicians into the post-stroke decision process might hinder avoidable obstacles.

Published
2024
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17. Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19

Author

Reinshagen, Leander, additional, Nageswaran, Vanasa, additional, Heidecke, Harald, additional, Schulze-Forster, Kai, additional, Wilde, Anne-Christin Beatrice, additional, Ramezani Rad, Pegah, additional, Poller, Wolfgang, additional, Asmus, Erik, additional, Simmons, Szandor, additional, Kuebler, Wolfgang M., additional, Witzenrath, Martin, additional, Markó, Lajos, additional, Jakobs, Kai, additional, Puccini, Marianna, additional, Leistner, David M., additional, Rauch-Kröhnert, Ursula, additional, Kränkel, Nicolle, additional, Forslund, Sofia K., additional, Landmesser, Ulf, additional, Müller, Dominik N., additional, and Haghikia, Arash, additional

Published
2023
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19. Patient-reported functional and symptomatic outcomes in patients with mild cognitive disorder undergoing transcatheter aortic valve implantation - A secondary analysis of a randomized controlled trial

Author

Thevathasan, T, primary, Hornig, C, additional, Leistner, D M, additional, Suendermann, S, additional, Unbehaun, A, additional, Sherif, M, additional, Haghikia, A, additional, Stangl, K, additional, Falk, V, additional, Landmesser, U, additional, Dreger, H, additional, Stangl, V, additional, and Brand, A, additional

Published
2023
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20. Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma

Author

Dumitru, Claudia Alexandra, primary, Schröder, Hannah, additional, Schäfer, Frederik Till Alexander, additional, Aust, Jan Friedrich, additional, Kreße, Nina, additional, Siebert, Carl Ludwig Raven, additional, Stein, Klaus-Peter, additional, Haghikia, Aiden, additional, Wilkens, Ludwig, additional, Mawrin, Christian, additional, and Sandalcioglu, Ibrahim Erol, additional

Published
2023
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24. Vessel distance mapping: A novel methodology for assessing vascular-induced cognitive resilience

Author

Garcia-Garcia, Berta, primary, Mattern, Hendrik, additional, Vockert, Niklas, additional, Yakupov, Renat, additional, Schreiber, Frank, additional, Spallazzi, Marco, additional, Perosa, Valentina, additional, Haghikia, Aiden, additional, Speck, Oliver, additional, Düzel, Emrah, additional, Maass, Anne, additional, and Schreiber, Stefanie, additional

Published
2023
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25. Effects of transcutaneous auricular vagus nerve stimulation paired with tones on electrophysiological markers of auditory perception

Author

Katharina S. Rufener, Christian Wienke, Alena Salanje, Aiden Haghikia, and Tino Zaehle

Subjects
Transcutaneous vagus nerve stimulation, Auditory cortex, Tone pairing, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has been introduced as a non-invasive alternative to invasive vagus nerve stimulation (iVNS). While iVNS paired with tones has been highlighted as a potential effective therapy for the treatment of auditory disorders such as tinnitus, there is still scarce data available confirming the efficacy of non-invasive taVNS. Here, we assessed the effect of taVNS paired with acoustic stimuli on sensory-related electrophysiological responses. Methods: A total of 22 healthy participants were investigated with a taVNS tone-pairing paradigm using a within-subjects design. In a single session pure tones paired with either active taVNS or sham taVNS were repeatedly presented. Novel tones without electrical stimulation served as control condition. Auditory event related potentials and auditory cortex oscillations were compared before and after the tone pairing procedure between stimulation conditions. Results: From pre to post pairing, we observed a decrease in the N1 amplitude and in theta power to tones paired with sham taVNS while these electrophysiological measures remained stable for tones paired with active taVNS a pattern mirroring auditory sensory processing of novel, unpaired control tones. Conclusion: Our results demonstrate the efficacy of a short-term application of non-invasive taVNS to modulate auditory processing in healthy individuals and, thereby, have potential implications for interventions in auditory processing deficits.

Published
2023
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27. A Molecular Biomarker-Based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms

Author

Guest, Paul C., Neyazi, Alexandra, Braun-Dullaeus, Rüdiger C., Müller, Patrick, Schreiber, Jens, Haghikia, Aiden, Vasilevska, Veronika, Steiner, Johann, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Guest, Paul C., editor

Published
2023
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30. Cystic fibrosis transmembrane conductance regulator potentiators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Author

Simmons, Szandor, primary, Asmus, Erik, additional, Karle, Weronika, additional, Brack, Markus, additional, Wittig, Corey, additional, Behrens, Felix, additional, Reinshagen, Leander, additional, Erfinanda, Lasti, additional, Michalick, Laura, additional, Smeele, Patrick, additional, van den Brom, Charissa, additional, Kaiser, Toralf, additional, Sander, Leif, additional, Landmesser, Ulf, additional, Haghikia, Arash, additional, Preissner, Robert, additional, Bogaard, Harm, additional, Witzenrath, Martin, additional, Kuebler, Wolfgang, additional, and Szulcek, Robert, additional

Published
2023
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31. Large-scale microRNA functional high-throughput screening identifies miR-515-3p and miR-519e-3p as inducers of human cardiomyocyte proliferation

Author

Renikunta, Harsha V., primary, Lazarow, Katina, additional, Gong, Yiqi, additional, Shukla, Praphulla Chandra, additional, Nageswaran, Vanasa, additional, Giral, Hector, additional, Kratzer, Adelheid, additional, Opitz, Lennart, additional, Engel, Felix B., additional, Haghikia, Arash, additional, Costantino, Sarah, additional, Paneni, Francesco, additional, von Kries, Jens Peter, additional, Streckfuss-Bömeke, Katrin, additional, Landmesser, Ulf, additional, and Jakob, Philipp, additional

Published
2023
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32. Left-ventricular unloading in extracorporeal cardiopulmonary resuscitation due to acute myocardial infarction – A multicenter study

Author

Thevathasan, Tharusan, primary, Kenny, Megan A., additional, Krause, Finn J., additional, Paul, Julia, additional, Wurster, Thomas, additional, Boie, Sebastian D., additional, Friebel, Julian, additional, Knie, Wulf, additional, Girke, Georg, additional, Haghikia, Arash, additional, Reinthaler, Markus, additional, Rauch-Kröhnert, Ursula, additional, Leistner, David M., additional, Sinning, David, additional, Fröhlich, Georg, additional, Heidecker, Bettina, additional, Spillmann, Frank, additional, Praeger, Damaris, additional, Pieske, Burkert, additional, Stangl, Karl, additional, Landmesser, Ulf, additional, Balzer, Felix, additional, and Skurk, Carsten, additional

Published
2023
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33. Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19

Author

Puccini, Marianna, primary, Jakobs, Kai, additional, Reinshagen, Leander, additional, Friebel, Julian, additional, Schencke, Philipp-Alexander, additional, Ghanbari, Emily, additional, Landmesser, Ulf, additional, Haghikia, Arash, additional, Kränkel, Nicolle, additional, and Rauch, Ursula, additional

Published
2023
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36. Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Author

Asmus, Erik, primary, Karle, Weronika, additional, Brack, Markus C., additional, Wittig, Corey, additional, Behrens, Felix, additional, Reinshagen, Leander, additional, Pfeiffer, Moritz, additional, Schulz, Sabrina, additional, Mandzimba-Maloko, Bertina, additional, Erfinanda, Lasti, additional, Perret, Paul L., additional, Michalick, Laura, additional, Smeele, Patrick J., additional, Lim, Endry H.T., additional, van den Brom, Charissa E., additional, Vonk, Alexander B.A., additional, Kaiser, Toralf, additional, Suttorp, Norbert, additional, Hippenstiel, Stefan, additional, Sander, Leif E., additional, Kurth, Florian, additional, Rauch, Ursula, additional, Landmesser, Ulf, additional, Haghikia, Arash, additional, Preissner, Robert, additional, Bogaard, Harm J., additional, Witzenrath, Martin, additional, Kuebler, Wolfgang M., additional, Szulcek, Robert, additional, and Simmons, Szandor, additional

Published
2023
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37. Effects of repetitive twice-weekly transcranial direct current stimulations on fatigue and fatigability in people with multiple sclerosis

Author

Stefanie Linnhoff, Aiden Haghikia, and Tino Zaehle

Subjects
Medicine, Science
Abstract

Abstract Fatigue is associated with a dramatically decreased quality of life in people with multiple sclerosis (pwMS). It refers to a constant subjective feeling of exhaustion and performance decline, known as fatigability. However, inconsistency and heterogeneity in defining and assessing fatigue have led to limited advances in understanding and treating MS-associated fatigue. Transcranial direct current stimulation (tDCS) has emerged as a promising, non-pharmaceutical treatment strategy for subjective fatigue. However, whether repetitive tDCS also have long-term effects on time-on-task performance has not yet been investigated. This pseudorandomized, single-blinded, and sham-controlled study investigated tDCS effects on behavioral and electrophysiological parameters. 18 pwMS received eight twice-weekly 30 min stimulations over the left dorsolateral prefrontal cortex. Fatigability was operationalized as time-on-task-related changes in reaction time variability and P300 amplitude. Additionally, subjective trait and state fatigue ratings were assessed. The results revealed an overall decrease in subjective trait fatigue ratings that lasted at least four weeks after the stimulations. However, the ratings declined after both anodal and sham tDCS. No effects were found on subjective state fatigue and objective fatigability parameters. Linear Mixed Models and Bayesian Regression models likewise favored the absence of a tDCS effect on fatigability parameters. The results confirm the complex relationship between MS-associated fatigue and fatigability. Reliable and clinically relevant parameters need to be established to extend the potential of tDCS for treating fatigability. Furthermore, our results indicate that consecutive stimulations rather than twice-weekly stimulations should be the preferred stimulation scheme in future studies.

Published
2023
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38. Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system

Author

Grüter, Thomas, primary, Mohamad, Nuwin, additional, Rilke, Niklas, additional, Blusch, Alina, additional, Sgodzai, Melissa, additional, Demir, Seray, additional, Pedreiturria, Xiomara, additional, Lemhoefer, Katharina, additional, Gisevius, Barbara, additional, Haghikia, Aiden, additional, Fisse, Anna Lena, additional, Motte, Jeremias, additional, Gold, Ralf, additional, and Pitarokoili, Kalliopi, additional

Published
2023
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44. Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure

Author

Romano, Kymberleigh A., primary, Nemet, Ina, additional, Prasad Saha, Prasenjit, additional, Haghikia, Arash, additional, Li, Xinmin S., additional, Mohan, Maradumane L., additional, Lovano, Beth, additional, Castel, Laurie, additional, Witkowski, Marco, additional, Buffa, Jennifer A., additional, Sun, Yu, additional, Li, Lin, additional, Menge, Christopher M., additional, Demuth, Ilja, additional, König, Maximilian, additional, Steinhagen-Thiessen, Elisabeth, additional, DiDonato, Joseph A., additional, Deb, Arjun, additional, Bäckhed, Fredrik, additional, Tang, W.H. Wilson, additional, Naga Prasad, Sathyamangla Venkata, additional, Landmesser, Ulf, additional, Van Wagoner, David R., additional, and Hazen, Stanley L., additional

Published
2023
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47. tRNA-like Transcripts from the NEAT1-MALAT1 Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions

Author

Gast, Martina, primary, Nageswaran, Vanasa, additional, Kuss, Andreas W., additional, Tzvetkova, Ana, additional, Wang, Xiaomin, additional, Mochmann, Liliana H., additional, Rad, Pegah Ramezani, additional, Weiss, Stefan, additional, Simm, Stefan, additional, Zeller, Tanja, additional, Voelzke, Henry, additional, Hoffmann, Wolfgang, additional, Völker, Uwe, additional, Felix, Stefan B., additional, Dörr, Marcus, additional, Beling, Antje, additional, Skurk, Carsten, additional, Leistner, David-Manuel, additional, Rauch, Bernhard H., additional, Hirose, Tetsuro, additional, Heidecker, Bettina, additional, Klingel, Karin, additional, Nakagawa, Shinichi, additional, Poller, Wolfram C., additional, Swirski, Filip K., additional, Haghikia, Arash, additional, and Poller, Wolfgang, additional

Published
2022
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48. Vessel distance mapping: A novel methodology for assessing vascular-induced cognitive resilience

Author

Berta Garcia-Garcia, Hendrik Mattern, Niklas Vockert, Renat Yakupov, Frank Schreiber, Marco Spallazzi, Valentina Perosa, Aiden Haghikia, Oliver Speck, Emrah Düzel, Anne Maass, and Stefanie Schreiber

Subjects
Vessel distance mapping, circle of Willis, Hippocampus, Cerebral small vessel disease, cognition, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The association between cerebral blood supply and cognition has been widely discussed in the recent literature. One focus of this discussion has been the anatomical variability of the circle of Willis, with morphological differences being present in more than half of the general population. While previous studies have attempted to classify these differences and explore their contribution to hippocampal blood supply and cognition, results have been controversial. To disentangle these previously inconsistent findings, we introduce Vessel Distance Mapping (VDM) as a novel methodology for evaluating blood supply, which allows for obtaining vessel pattern metrics with respect to the surrounding structures, extending the previously established binary classification into a continuous spectrum. To accomplish this, we manually segmented hippocampal vessels obtained from high-resolution 7T time-of-flight MR angiographic imaging in older adults with and without cerebral small vessel disease, generating vessel distance maps by computing the distances of each voxel to its nearest vessel. Greater values of VDM-metrics, which reflected higher vessel distances, were associated with poorer cognitive outcomes in subjects affected by vascular pathology, while this relation was not observed in healthy controls. Therefore, a mixed contribution of vessel pattern and vessel density is proposed to confer cognitive resilience, consistent with previous research findings. In conclusion, VDM provides a novel platform, based on a statistically robust and quantitative method of vascular mapping, for addressing a variety of clinical research questions.

Published
2023
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